Accessibility for Ontarians with Disabilities Act (AODA) Practice Exam

What mechanism is commonly involved in the therapeutic effects of opioids?

1. Endorphin release

2. Serotonin reuptake inhibition

3. Dopamine receptor activation

4. Norepinephrine antagonism

The correct answer is: Endorphin release

The mechanism that is commonly involved in the therapeutic effects of opioids is the release of endorphins. Opioids work primarily by binding to specific receptors in the brain and spinal cord known as opioid receptors. When these receptors are activated, they lead to a cascade of effects that include the release of endogenous opioids, such as endorphins, which are natural pain-relieving chemicals produced by the body. The therapeutic actions of opioids, such as pain relief and euphoria, are largely attributed to this endorphin release. By mimicking the action of endorphins, opioids can effectively reduce the perception of pain as well as induce feelings of pleasure, which can assist in addressing severe pain conditions. The other mechanisms listed, like serotonin reuptake inhibition, dopamine receptor activation, and norepinephrine antagonism, pertain to different classes of drugs used for various conditions, such as antidepressants or antipsychotics, and do not directly relate to the primary action of opioids. Opioids distinctly engage with the body’s pain relief system through the endorphin pathway, underscoring the importance of understanding their specific action in therapeutic contexts.